P01 - IgE and IgG1 clonotypes in food allergy

2025

de Almeida LN, Petry J, Udoye CC. Type 2 IgG Memory B Cells as Precursors of IgE Plasma Cells. Allergy. 2025 Mar;80(3):908-910. doi: 10.1111/all.16473. Epub 2025 Jan 11. PMID: 39797576.

Udoye C, Rau C, Clauder AK, Lindemann T, Almeida L, Goetzie J, et al. Divergent IgE to IgG hypermutation is associated with allergic hypothermia in mice. Authorea [Preprint]. 2025 Aug 13. doi: 10.22541/au.175510288.82248699/v1.

2023

Udoye CC, Ehlers M, Manz RA. The B Cell Response and Formation of Allergenic and Anti-Allergenic Antibodies in Food Allergy. Biology (Basel). 2023 Dec 7;12(12):1501. doi: 10.3390/biology12121501. PMID: 38132327.

2022

Udoye CC, Rau CN, Freye SM, Almeida LN, Vera-Cruz S, Othmer K, et al. B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy. Mucosal Immunol. 2022 Jun;15(6):1375-1388. doi: 10.1038/s41385-022-00567-y. Epub 2022 Sep 16. PMID: 36114245.

P02 - Antibody glycosylation and allergic responses

2025

Buhre JS, Pongracz T, Geisen UM, Schubert M, Wang W, Nouta J, et al. Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination. Allergy. 2025 Feb;80(2):423-439. doi: 10.1111/all.16241. Epub 2024 Jul 25. PMID: 39049686.

Ehlers M, Jönsson F. Pathogenic and Nonpathogenic Antibody Responses in Allergic Diseases. Eur J Immunol. 2025 Mar;55(3):e202249978. doi: 10.1002/eji.202249978. Epub 2024 Dec 29. PMID: 40071673.

Lehrian S, Wasynczuk A, Petry J, Guderian M, Nouta J, Buhre JS, et al. Anti-tumor vaccine efficacy depends on adjuvant type and associates with induced IgG subclass and glycosylation profiles. Exp Hematol Oncol. 2025 Oct 6;14(1):122. doi: 10.1186/s40164-025-00708-6. PMID: 41053886.

2023

Dühring L, Petry J, Lilienthal GM, Bartsch YC, Kubiak M, Pfeufer C, et al. Sialylation of IgE reduces FcεRIα interaction and mast cell and basophil activation in vitro and increases IgE half-life in vivo. Allergy. 2023 Aug;78(8):2301-2305. doi: 10.1111/all.15665. Epub 2023 Feb 13. PMID: 36724158.

2021

Petry J, Rahmöller J, Dühring L, Lilienthal GM, Lehrian S, Buhre JS, et al. Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions. J Allergy Clin Immunol. 2021 Feb;147(2):763-767. doi: 10.1016/j.jaci.2020.05.056. Epub 2020 Jun 27. PMID: 32603664.

2020

Bartsch YC, Eschweiler S, Leliavski A, Lunding HB, Wagt S, Petry J, et al. IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants. J Allergy Clin Immunol. 2020 Sep;146(3):652-666.e11. doi: 10.1016/j.jaci.2020.04.059. Epub 2020 May 21. PMID: 32445838.

2018

Epp A, Hobusch J, Bartsch YC, Petry J, Lilienthal GM, Koeleman CAM, et al. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J Allergy Clin Immunol. 2018 Jan;141(1):399-402.e8. doi: 10.1016/j.jaci.2017.06.021. Epub 2017 Jul 18. PMID: 28728998.

2015

Strait RT, Posgai MT, Mahler A, Barasa N, Jacob CO, Köhl J, et al. IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Nature. 2015 Jan 22;517(7535):501-4. doi: 10.1038/nature13868. Epub 2014 Nov 2. PMID: 25363774.

P03 - Diet and B cell responses in atopic dermatitis

2024

Zirpel H, Ständer S, Frączek A, Olbrich H, Ludwig RJ, Thaçi D. Atopic dermatitis is associated with an increased risk of cardiovascular diseases: a large-scale, propensity-score matched US-based retrospective study. Clin Exp Dermatol. 2024 Oct 24;49(11):1405-1412. doi: 10.1093/ced/llae164. PMID: 38703379.

2023

Gupta Y, Ernst AL, Vorobyev A, Beltsiou F, Zillikens D, Bieber K, et al. Impact of diet and host genetics on the murine intestinal mycobiome. Nat Commun. 2023 Feb 14;14(1):834. doi: 10.1038/s41467-023-36479-z. PMID: 36788222.

Olbrich H, Sadik CD, Ludwig RJ, Thaçi D, Boch K. Dupilumab in Inflammatory Skin Diseases: A Systematic Review. Biomolecules. 2023 Mar 31;13(4):634. doi: 10.3390/biom13040634. PMID: 37189381.

2019

Vorobyev A, Gupta Y, Sezin T, Koga H, Bartsch YC, Belheouane M, et al. Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line. Nat Commun. 2019 Sep 10;10(1):4097. doi: 10.1038/s41467-019-11952-w. PMID: 31506438.

2013

Schindewolf M, Gobst C, Kroll H, Recke A, Louwen F, Wolter M, et al. High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy. J Allergy Clin Immunol. 2013 Jul;132(1):131-9. doi: 10.1016/j.jaci.2013.02.047. Epub 2013 May 30. PMID: 23726261.

P04 - Engineering antibodies with allergenic and protective functions

2026

Fischer C, Chen SS, Nimmerfroh J, Eugster A, Stücheli S, Schultheiß C, et al. IGLV3-21R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia. Haematologica. 2026 Feb 1;111(2):572-582. doi: 10.3324/haematol.2025.287697. Epub 2025 Sep 11. PMID: 40931870.

2024

Krohn S, Holtrop T, Brandsma AM, Moerer P, Nederend M, Darzentas N, et al. Combining Cellular Immunization and Phage Display Screening Results in Novel, FcγRI-Specific Antibodies. Viruses. 2024 Apr 12;16(4):596. doi: 10.3390/v16040596. PMID: 38675937.

Windisch R, Soliman S, Hoffmann A, Chen-Wichmann L, Danese A, Vosberg S, et al. Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2312499121. doi: 10.1073/pnas.2312499121. Epub 2024 Jun 10. PMID: 38857395.

2022

Gehlert CL, Rahmati P, Boje AS, Winterberg D, Krohn S, Theocharis T, et al. Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody. Front Immunol. 2022;13:957874. doi: 10.3389/fimmu.2022.957874. Epub 2022 Aug 31. PMID: 36119088.

Klausz K, Pekar L, Boje AS, Gehlert CL, Krohn S, Gupta T, et al. Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release. J Immunol. 2022 Nov 1;209(9):1724-1735. doi: 10.4049/jimmunol.2100970. Epub 2022 Sep 14. PMID: 36104113.

2021

Khodoun MV, Morris SC, Shao WH, Potter C, Angerman E, Kiselev A, et al. Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs. J Allergy Clin Immunol. 2021 May;147(5):1838-1854.e4. doi: 10.1016/j.jaci.2020.10.045. Epub 2020 Dec 14. PMID: 33326804.

Pekar L, Klausz K, Busch M, Valldorf B, Kolmar H, Wesch D, et al. Affinity Maturation of B7-H6 Translates into Enhanced NK Cell-Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement. J Immunol. 2021 Jan 1;206(1):225-236. doi: 10.4049/jimmunol.2001004. Epub 2020 Dec 2. PMID: 33268483.

P05 - IgG4 B cells and tolerance to aeroallergens

2025

Stoumpos A, Heine G, Saggau C, Scheffold A. The role of allergen-specific regulatory T cells in the control of allergic disease. Curr Opin Immunol. 2025 Feb;92:102509. doi: 10.1016/j.coi.2024.102509. Epub 2024 Dec 6. PMID: 39642798.

2023

Seidl U, Bohne AS, Kaeding M, Bauer L, Weichenthal M, Wehkamp U, et al. Angiolymphoid hyperplasia with eosinophilia infiltrated by GATA3+ Th2 cells responding to dupilumab. J Eur Acad Dermatol Venereol. 2023 Apr 15. doi: 10.1111/jdv.19116. PMID: 37060261.

2022

Kühl J, Bergh B, Laudes M, Szymczak S, Heine G. Cofactors of drug hypersensitivity-A monocenter retrospective analysis. Front Allergy. 2022;3:1097977. doi: 10.3389/falgy.2022.1097977. Epub 2023 Jan 6. PMID: 36686964.

2021

Heine G, Francuzik W, Doelle-Bierke S, Drozdenko G, Frischbutter S, Schumacher N, et al. Immunomodulation of high-dose vitamin D supplementation during allergen-specific immunotherapy. Allergy. 2021 Mar;76(3):930-933. doi: 10.1111/all.14541. Epub 2020 Sep 25. PMID: 32750735.

Scholz J, Kuhrau J, Heinrich F, Heinz GA, Hutloff A, Worm M, et al. Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation. Allergy. 2021 Apr;76(4):1109-1122. doi: 10.1111/all.14581. Epub 2020 Sep 20. PMID: 32895937.

2018

Heine G, Hollstein T, Treptow S, Radbruch A, Worm M. 9-cis retinoic acid modulates the type I allergic immune response. J Allergy Clin Immunol. 2018 Feb;141(2):650-658.e5. doi: 10.1016/j.jaci.2017.03.046. Epub 2017 May 17. PMID: 28526622.

2016

Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, et al. Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell. 2016 Nov 3;167(4):1067-1078.e16. doi: 10.1016/j.cell.2016.09.050. Epub 2016 Oct 20. PMID: 27773482.

2014

Heine G, Drozdenko G, Grün JR, Chang HD, Radbruch A, Worm M. Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts. Eur J Immunol. 2014 Jun;44(6):1615-21. doi: 10.1002/eji.201343822. Epub 2014 Mar 11. PMID: 24643722.

P06 - Lung resident B cells and IgA immunity

2025

Schacht SS, Graffunder J, Durek P, Wehrenberg J, Siracusa A, Biese C, et al. Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node. Cell Mol Immunol. 2025 Jun;22(6):612-627. doi: 10.1038/s41423-025-01285-8. Epub 2025 Apr 11. PMID: 40210692.

2024

Ferreira-Gomes M, Chen Y, Durek P, Rincon-Arevalo H, Heinrich F, Bauer L, et al. Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow. Nat Commun. 2024 May 17;15(1):4182. doi: 10.1038/s41467-024-48570-0. PMID: 38755157.

Saggau C, Bacher P, Esser D, Rasa M, Meise S, Mohr N, et al. Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases. Immunity. 2024 Oct 8;57(10):2416-2432.e8. doi: 10.1016/j.immuni.2024.08.005. Epub 2024 Sep 2. PMID: 39226901.

2021

Bauer L, Müller LJ, Volkers SM, Heinrich F, Mashreghi MF, Ruppert C, et al. Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis. Am J Respir Crit Care Med. 2021 Dec 15;204(12):1403-1417. doi: 10.1164/rccm.202012-4423OC. PMID: 34534436.

Ritzau-Jost J, Hutloff A. T Cell/B Cell Interactions in the Establishment of Protective Immunity. Vaccines (Basel). 2021 Sep 24;9(10):1074. doi: 10.3390/vaccines9101074. PMID: 34696182.

P07 - Autoreactive B cells in granulomatosis with polyangiitis

2026

von Allwörden K, Klapa S, Werth SC, Leheis A, Graßhoff H, Müller A, et al. Real-world outcomes of rituximab- and cyclophosphamide-based induction therapy regimens alone and in combination over 24 months in ANCA-associated vasculitis. Clin Exp Rheumatol. 2026 Apr;44(4):663-669. doi: 10.55563/clinexprheumatol/cfyh9p. Epub 2025 Sep 2. PMID: 40892637.

2024

Falde SD, Fussner LA, Tazelaar HD, O'Brien EK, Lamprecht P, Konig MF, et al. Proteinase 3-specific antineutrophil cytoplasmic antibody-associated vasculitis. Lancet Rheumatol. 2024 May;6(5):e314-e327. doi: 10.1016/S2665-9913(24)00035-3. Epub 2024 Apr 1. PMID: 38574742.

2023

Klapa S, Müller A, Koch A, Kerstein-Stähle A, Kähler W, Heidecke H, et al. Low Concentrations of C5a Complement Receptor Antibodies Are Linked to Disease Activity and Relapse in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. Arthritis Rheumatol. 2023 May;75(5):760-767. doi: 10.1002/art.42410. Epub 2023 Feb 22. PMID: 36409567.

2021

Yue X, Petersen F, Shu Y, Kasper B, Magatsin JDT, Ahmadi M, et al. Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice. Front Immunol. 2021;12:677970. doi: 10.3389/fimmu.2021.677970. Epub 2021 Jun 23. PMID: 34248959.

2018

Cabral-Marques O, Marques A, Giil LM, De Vito R, Rademacher J, Günther J, et al. GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis. Nat Commun. 2018 Dec 6;9(1):5224. doi: 10.1038/s41467-018-07598-9. PMID: 30523250.

Weppner G, Ohlei O, Hammers CM, Holl-Ulrich K, Voswinkel J, Bischof J, et al. In situ detection of PR3-ANCA+ B cells and alterations in the variable region of immunoglobulin genes support a role of inflamed tissue in the emergence of auto-reactivity in granulomatosis with polyangiitis. J Autoimmun. 2018 Sep;93:89-103. doi: 10.1016/j.jaut.2018.07.004. Epub 2018 Jul 24. PMID: 30054207.

P08 - B cell metabolism and mucosal immunity in Crohn disease

2026

Raschdorf A, de Almeida LN, Solbach P, Kirstein MM, Marquardt JU, Schmelter F, et al. Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease. Nat Commun. 2026 Feb 12;17(1):1590. doi: 10.1038/s41467-026-69069-w. PMID: 41680132.

2025

de Almeida LN, Petry J, Udoye CC. Type 2 IgG Memory B Cells as Precursors of IgE Plasma Cells. Allergy. 2025 Mar;80(3):908-910. doi: 10.1111/all.16473. Epub 2025 Jan 11. PMID: 39797576.

2024

Ragab M, Schlichting H, Hicken M, Mester P, Hirose M, Almeida LN, et al. Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn's disease severity. Sci Rep. 2024 Jun 5;14(1):12879. doi: 10.1038/s41598-024-63730-4. PMID: 38839896.

Tews HC, Schmelter F, Kandulski A, Büchler C, Schmid S, Schlosser S, et al. Unique Metabolomic and Lipidomic Profile in Serum From Patients With Crohn's Disease and Ulcerative Colitis Compared With Healthy Control Individuals. Inflamm Bowel Dis. 2024 Dec 5;30(12):2405-2417. doi: 10.1093/ibd/izad298. PMID: 38156773.

2021

Sünderhauf A, Hicken M, Schlichting H, Skibbe K, Ragab M, Raschdorf A, et al. Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative Colitis. Cell Mol Gastroenterol Hepatol. 2021;12(1):229-250. doi: 10.1016/j.jcmgh.2021.01.017. Epub 2021 Jan 27. PMID: 33515804.

2020

Derer S, Brethack AK, Pietsch C, Jendrek ST, Nitzsche T, Bokemeyer A, et al. Inflammatory Bowel Disease-associated GP2 Autoantibodies Inhibit Mucosal Immune Response to Adherent-invasive Bacteria. Inflamm Bowel Dis. 2020 Nov 19;26(12):1856-1868. doi: 10.1093/ibd/izaa069. PMID: 32304568.

Raschdorf A, Sünderhauf A, Skibbe K, Ghebrehiwet B, Peerschke EI, Sina C, et al. Heterozygous P32/C1QBP/HABP1 Polymorphism rs56014026 Reduces Mitochondrial Oxidative Phosphorylation and Is Expressed in Low-grade Colorectal Carcinomas. Front Oncol. 2020;10:631592. doi: 10.3389/fonc.2020.631592. Epub 2021 Feb 8. PMID: 33628739.

Sünderhauf A, Raschdorf A, Hicken M, Schlichting H, Fetzer F, Brethack AK, et al. GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells. Front Oncol. 2020;10:575854. doi: 10.3389/fonc.2020.575854. Epub 2020 Sep 30. PMID: 33102234.

2019

Meng L, Almeida LN, Clauder AK, Lindemann T, Luther J, Link C, et al. Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10. Front Immunol. 2019;10:1183. doi: 10.3389/fimmu.2019.01183. Epub 2019 May 31. PMID: 31214168.

Preisker S, Brethack AK, Bokemeyer A, Bettenworth D, Sina C, Derer S. Crohn's Disease Patients in Remission Display an Enhanced Intestinal IgM⁺ B Cell Count in Concert with a Strong Activation of the Intestinal Complement System. Cells. 2019 Jan 21;8(1):78. doi: 10.3390/cells8010078. PMID: 30669641.

2018

Sina C, Kemper C, Derer S. The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function. Semin Immunol. 2018 Jun;37:66-73. doi: 10.1016/j.smim.2018.02.008. Epub 2018 Feb 24. PMID: 29486961.

2017

Jendrek ST, Gotthardt D, Nitzsche T, Widmann L, Korf T, Michaels MA, et al. Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Gut. 2017 Jan;66(1):137-144. doi: 10.1136/gutjnl-2016-311739. Epub 2016 Jul 12. PMID: 27406039.

2015

Michaels MA, Jendrek ST, Korf T, Nitzsche T, Teegen B, Komorowski L, et al. Pancreatic Autoantibodies Against CUZD1 and GP2 Are Associated with Distinct Clinical Phenotypes of Crohn's Disease. Inflamm Bowel Dis. 2015 Dec;21(12):2864-72. doi: 10.1097/MIB.0000000000000564. PMID: 26273818.

P09 - Artificial intelligence for cytometric analysis of rare B cell subsets

2025

Bao R, Feng M, Wang M, Liu Y, Hu L, Yao Y. Detection of acute myeloid leukemia and remission states using heterogeneous flow cytometry data. Front Oncol. 2025;15:1638074. doi: 10.3389/fonc.2025.1638074. Epub 2025 Sep 30. PMID: 41098697.

Quan Q, Ju X, Li G, Ye L, Ren S, Yang S, et al. Simplified flow cytometry-based assay for rapid multi-cytokine profiling and machine-learning-assisted diagnosis of inflammatory diseases. Front Pharmacol. 2025;16:1594141. doi: 10.3389/fphar.2025.1594141. Epub 2025 Jun 27. PMID: 40657638.

2023

Suchanek O, Ferdinand JR, Tuong ZK, Wijeyesinghe S, Chandra A, Clauder AK, et al. Tissue-resident B cells orchestrate macrophage polarisation and function. Nat Commun. 2023 Nov 4;14(1):7081. doi: 10.1038/s41467-023-42625-4. PMID: 37925420.

2021

Clauder AK, Kordowski A, Bartsch YC, Köhl G, Lilienthal GM, Almeida LN, et al. IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease. J Invest Dermatol. 2021 Feb;141(2):285-294. doi: 10.1016/j.jid.2020.06.022. Epub 2020 Jul 10. PMID: 32653301.

Cossarizza A, Chang HD, Radbruch A, Abrignani S, Addo R, Akdis M, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). Eur J Immunol. 2021 Dec;51(12):2708-3145. doi: 10.1002/eji.202170126. Epub 2021 Dec 7. PMID: 34910301.

P10 - Diet-dependent mitogenetic, metabolic, and regulatory states of B cell memory